Genomics Laboratory

• Identification of polymorphisms of marker genes of various diseases.
• Study of candidate gene polymorphisms associated with multidrug resistance involved in drug metabolism.
• Development of regional molecular-genetic test systems for disease diagnosis and pharmacotherapy.
• Diagnosis of drug resistance level and genetic testing by polymorphic marker gene in oncological diseases.

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• Polymorphisms of candidate genes associated with hereditary, endocrine, oncological, cardiovascular and other diseases were studied.
• Virulence genes of H.pylori bacteria associated with gastroenterological diseases were studied. A molecular-genetic PCR test system was developed for local pathogen isolates.
• Genotypes of cancer patients resistant or sensitive to chemotherapy by polymorphic marker gene were identified.
• Functional activity of P-glycoprotein in breast cancer was studied before and after neoadjuvant chemotherapy.

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• Molecular-genetic tests were created and implemented into healthcare practice.
• Results obtained on the epigenetics of marker genes of oncological diseases are being implemented in clinical practice.
• Polymorphisms of candidate genes associated with multidrug resistance are being implemented in clinical practice.
• Results of chemotherapy treatment based on genetic testing are being implemented in clinical practice.

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• Medical Academy of the Republic of Uzbekistan
• Research Institute of Obstetrics and Gynecology, Ministry of Health of the Republic of Uzbekistan
• Research Institute of Dermatology and Venereology, Ministry of Health of the Republic of Uzbekistan
• Urgench Branch of Tashkent Medical Academy
• Republican AIDS Center

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• Development of a test panel for molecular-genetic diagnosis of hereditary, endocrine, oncological, cardiovascular and other diseases in Uzbekistan.
• Study of marker gene expression levels and epigenetic mechanisms of age-related diseases.
• Study of candidate gene polymorphisms associated with multidrug resistance involved in drug metabolism.
• Analysis and evaluation of the effectiveness of AIDS therapy to prevent drug resistance to antiretroviral drugs.

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